The security certificate on the server is invalid. Contact your Exchange Server administrator or ISP to install a valid certificate on the server. Support Code: 80072F0D or 0x80072f0d

I had some Mobile device that did not sync anymore. I changed the Certificates on 2007 and Servers.

After some investing. The problem was I was missing the GlobalSign Domain Validation CA certificate

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After creating the cer file and installed on my PDA active sync works again.

Source:
http://support.microsoft.com/kb/927465

http://support.microsoft.com/kb/915438

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